Drug interactions
Carisoprodol + Perphenazine
Severity: Moderate
Carisoprodol and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine and carisoprodol both depress CNS function. Together they can cause excessive drowsiness, impaired coordination and orthostatic hypotension.
What this interaction means in plain words
Carisoprodol and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carisoprodol belongs to Musculoskeletal; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for oversedation and orthostatic hypotension, and use the lowest effective doses. Advise the patient against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carisoprodol
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Carisoprodol with Perphenazine?
MediHelp rates the interaction as moderate. Carisoprodol and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine and carisoprodol both depress CNS function. Together they can cause excessive drowsiness, impaired coordination and orthostatic hypotension.
How serious is the interaction between Carisoprodol and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and orthostatic hypotension, and use the lowest effective doses. Advise the patient against driving and alcohol.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
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