Drug interactions
Carisoprodol + Promethazine
Severity: Moderate
Carisoprodol and Promethazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and combined use can increase drowsiness, dizziness and impaired coordination. Risk is greater in older adults and with higher doses.
What this interaction means in plain words
Carisoprodol and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carisoprodol belongs to Musculoskeletal; Promethazine belongs to Respiratory.
Why it happens
Additive central nervous system depression.
What to do
Use the lowest effective doses and warn patients about driving and operating machinery. Monitor for excessive sedation and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Other interactions of Carisoprodol
Frequently asked questions
Can I take Carisoprodol with Promethazine?
MediHelp rates the interaction as moderate. Carisoprodol and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and combined use can increase drowsiness, dizziness and impaired coordination. Risk is greater in older adults and with higher doses.
How serious is the interaction between Carisoprodol and Promethazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and warn patients about driving and operating machinery. Monitor for excessive sedation and falls.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Cabergoline, Dopamine, Ibutilide. The full list is on the Promethazine page.
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