Drug interactions
Carmustine + Cisplatin
Severity: Moderate
Carmustine and Cisplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause myelosuppression, with carmustine producing delayed and cumulative marrow toxicity. Combining them can cause prolonged neutropenia and thrombocytopenia with infection and bleeding risks.
What this interaction means in plain words
Carmustine and Cisplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carmustine belongs to Oncology; Cisplatin belongs to Oncology.
Why it happens
Additive bone marrow suppression from DNA-damaging agents.
What to do
Monitor blood counts frequently, including at the delayed nadir, and adjust doses or delay cycles for cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Other interactions of Carmustine
- Carmustine + Pentostatin Contraindicated
- Carmustine + Chlorambucil Major
- Carmustine + Cimetidine Major
- Carmustine + Cyclophosphamide Major
- Carmustine + Dacarbazine Major
- Carmustine + Fingolimod Major
Frequently asked questions
Can I take Carmustine with Cisplatin?
MediHelp rates the interaction as moderate. Carmustine and Cisplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause myelosuppression, with carmustine producing delayed and cumulative marrow toxicity. Combining them can cause prolonged neutropenia and thrombocytopenia with infection and bleeding risks.
How serious is the interaction between Carmustine and Cisplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts frequently, including at the delayed nadir, and adjust doses or delay cycles for cytopenias.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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