Drug interactions
Carmustine + Denosumab
Severity: Moderate
Carmustine and Denosumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carmustine causes myelosuppression and immune suppression, and denosumab has been associated with serious infections. Combined use may increase infection risk, especially during neutropenia.
What this interaction means in plain words
Carmustine and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carmustine belongs to Oncology; Denosumab belongs to Oncology.
Why it happens
Additive immunosuppression from alkylating-agent myelosuppression and RANKL inhibition.
What to do
Monitor blood counts and infection signs during chemotherapy, and treat fever promptly. Hypocalcemia should also be checked during denosumab therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carmustine and Denosumab, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Carmustine
- Carmustine + Pentostatin Contraindicated
- Carmustine + Chlorambucil Major
- Carmustine + Cimetidine Major
- Carmustine + Cyclophosphamide Major
- Carmustine + Dacarbazine Major
- Carmustine + Fingolimod Major
Frequently asked questions
Can I take Carmustine with Denosumab?
MediHelp rates the interaction as moderate. Carmustine and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carmustine causes myelosuppression and immune suppression, and denosumab has been associated with serious infections. Combined use may increase infection risk, especially during neutropenia.
How serious is the interaction between Carmustine and Denosumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and infection signs during chemotherapy, and treat fever promptly. Hypocalcemia should also be checked during denosumab therapy.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
