Drug interactions
Carmustine + Hydroxycarbamide
Severity: Moderate
Carmustine and Hydroxycarbamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause bone marrow suppression. Combined use can produce deeper and more prolonged cytopenias, including delayed nadirs from carmustine.
What this interaction means in plain words
Carmustine and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carmustine belongs to Oncology; Hydroxycarbamide belongs to Oncology.
Why it happens
Additive myelosuppression.
What to do
Monitor complete blood counts weekly or more often, including after carmustine. Reduce doses or delay cycles if counts fall significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Other interactions of Carmustine
- Carmustine + Pentostatin Contraindicated
- Carmustine + Chlorambucil Major
- Carmustine + Cimetidine Major
- Carmustine + Cyclophosphamide Major
- Carmustine + Dacarbazine Major
- Carmustine + Fingolimod Major
Frequently asked questions
Can I take Carmustine with Hydroxycarbamide?
MediHelp rates the interaction as moderate. Carmustine and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause bone marrow suppression. Combined use can produce deeper and more prolonged cytopenias, including delayed nadirs from carmustine.
How serious is the interaction between Carmustine and Hydroxycarbamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts weekly or more often, including after carmustine. Reduce doses or delay cycles if counts fall significantly.
What other medicines interact with Hydroxycarbamide?
MediHelp also lists interactions of Hydroxycarbamide with, for example, Didanosine, Stavudine, Adenovirus types 4 and 7 live. The full list is on the Hydroxycarbamide page.
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