Drug interactions
Carvedilol + Clobazam
Severity: Minor
Carvedilol and Clobazam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a weak CYP2D6 inhibitor and may modestly increase exposure to carvedilol, a CYP2D6 substrate. Additive sedation and hypotension may also be noted.
What this interaction means in plain words
Carvedilol and Clobazam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Clobazam belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP2D6-mediated carvedilol metabolism.
What to do
Monitor heart rate and blood pressure when starting clobazam. Reduce carvedilol dose if bradycardia or hypotension appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carvedilol
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Carvedilol with Clobazam?
MediHelp rates the interaction as minor. Carvedilol and Clobazam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clobazam is a weak CYP2D6 inhibitor and may modestly increase exposure to carvedilol, a CYP2D6 substrate. Additive sedation and hypotension may also be noted.
How serious is the interaction between Carvedilol and Clobazam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting clobazam. Reduce carvedilol dose if bradycardia or hypotension appears.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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