Drug interactions
Carvedilol + Dacomitinib
Severity: Moderate
Carvedilol and Dacomitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib is a strong CYP2D6 inhibitor and can raise carvedilol exposure, since carvedilol is partly metabolized by CYP2D6. This can cause excess beta-blockade and hypotension.
What this interaction means in plain words
Carvedilol and Dacomitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Dacomitinib belongs to Oncology.
Why it happens
Inhibition of CYP2D6-mediated metabolism of carvedilol (mainly the R-enantiomer).
What to do
Monitor heart rate and blood pressure when starting dacomitinib. Lower the carvedilol dose if bradycardia, dizziness or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Carvedilol with Dacomitinib?
MediHelp rates the interaction as moderate. Carvedilol and Dacomitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dacomitinib is a strong CYP2D6 inhibitor and can raise carvedilol exposure, since carvedilol is partly metabolized by CYP2D6. This can cause excess beta-blockade and hypotension.
How serious is the interaction between Carvedilol and Dacomitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting dacomitinib. Lower the carvedilol dose if bradycardia, dizziness or hypotension occurs.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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