Drug interactions
Carvedilol + Darunavir
Severity: Moderate
Carvedilol and Darunavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, may increase carvedilol concentrations via CYP2D6 and P-gp inhibition. This can cause bradycardia and hypotension.
What this interaction means in plain words
Carvedilol and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Darunavir belongs to Anti Virals.
Why it happens
Inhibition of CYP2D6 and P-gp (mainly by the booster) reduces carvedilol clearance.
What to do
Monitor heart rate and blood pressure and titrate carvedilol cautiously. Lower the dose if bradycardia or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Carvedilol with Darunavir?
MediHelp rates the interaction as moderate. Carvedilol and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually boosted with ritonavir or cobicistat, may increase carvedilol concentrations via CYP2D6 and P-gp inhibition. This can cause bradycardia and hypotension.
How serious is the interaction between Carvedilol and Darunavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and titrate carvedilol cautiously. Lower the dose if bradycardia or hypotension occurs.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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