Drug interactions
Carvedilol + Dronedarone
Severity: Moderate
Carvedilol and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits CYP2D6 and P-glycoprotein, which can raise carvedilol exposure. Dronedarone also slows the heart rate and AV conduction, so the pair can cause additive bradycardia, AV block and hypotension.
What this interaction means in plain words
Carvedilol and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Dronedarone belongs to Cardiovascular.
Why it happens
Dronedarone inhibits CYP2D6 and P-glycoprotein, reducing carvedilol clearance, together with additive negative chronotropic and dromotropic effects.
What to do
Start carvedilol at a low dose and titrate based on heart rate, blood pressure and ECG findings. Reduce the carvedilol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Carvedilol with Dronedarone?
MediHelp rates the interaction as moderate. Carvedilol and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone inhibits CYP2D6 and P-glycoprotein, which can raise carvedilol exposure. Dronedarone also slows the heart rate and AV conduction, so the pair can cause additive bradycardia, AV block and hypotension.
How serious is the interaction between Carvedilol and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start carvedilol at a low dose and titrate based on heart rate, blood pressure and ECG findings. Reduce the carvedilol dose if bradycardia or hypotension develops.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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