Drug interactions
Carvedilol + Edoxaban
Severity: Moderate
Carvedilol and Edoxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol inhibits P-glycoprotein and may modestly raise edoxaban exposure. The effect is generally small and could slightly increase bleeding risk.
What this interaction means in plain words
Carvedilol and Edoxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Edoxaban belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein-mediated intestinal and renal efflux of edoxaban by carvedilol.
What to do
No routine dose change is needed; monitor for bleeding signs, particularly with renal impairment or low body weight.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Carvedilol with Edoxaban?
MediHelp rates the interaction as moderate. Carvedilol and Edoxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carvedilol inhibits P-glycoprotein and may modestly raise edoxaban exposure. The effect is generally small and could slightly increase bleeding risk.
How serious is the interaction between Carvedilol and Edoxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for bleeding signs, particularly with renal impairment or low body weight.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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