Drug interactions
Carvedilol + Eliglustat
Severity: Moderate
Carvedilol and Eliglustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits CYP2D6 and P-glycoprotein, both of which affect carvedilol disposition. Carvedilol levels may rise, increasing the risk of bradycardia, hypotension and dizziness.
What this interaction means in plain words
Carvedilol and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Eliglustat belongs to Miscellaneous.
Why it happens
Inhibition of CYP2D6 metabolism and P-glycoprotein efflux of carvedilol by eliglustat.
What to do
Monitor heart rate and blood pressure and consider reducing the carvedilol dose, titrating to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Carvedilol with Eliglustat?
MediHelp rates the interaction as moderate. Carvedilol and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat inhibits CYP2D6 and P-glycoprotein, both of which affect carvedilol disposition. Carvedilol levels may rise, increasing the risk of bradycardia, hypotension and dizziness.
How serious is the interaction between Carvedilol and Eliglustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and consider reducing the carvedilol dose, titrating to clinical response.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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