Drug interactions
Carvedilol + Fluvoxamine
Severity: Moderate
Carvedilol and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine is a strong CYP1A2 and CYP2C19 inhibitor with weaker effects on CYP2D6 and CYP2C9, so it may raise carvedilol concentrations modestly. The consequence is greater beta-blocking and vasodilating effect, with bradycardia, dizziness or hypotension in some patients.
What this interaction means in plain words
Carvedilol and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Fluvoxamine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6 and CYP2C9 by fluvoxamine reduces carvedilol metabolism.
What to do
Monitor heart rate and blood pressure when starting or stopping fluvoxamine. Reduce the carvedilol dose if symptomatic bradycardia or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Carvedilol with Fluvoxamine?
MediHelp rates the interaction as moderate. Carvedilol and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine is a strong CYP1A2 and CYP2C19 inhibitor with weaker effects on CYP2D6 and CYP2C9, so it may raise carvedilol concentrations modestly. The consequence is greater beta-blocking and vasodilating effect, with bradycardia, dizziness or hypotension in some patients.
How serious is the interaction between Carvedilol and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or stopping fluvoxamine. Reduce the carvedilol dose if symptomatic bradycardia or hypotension occurs.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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