Drug interactions
Carvedilol + Haloperidol
Severity: Moderate
Carvedilol and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol inhibits CYP2D6 to a modest degree and may increase carvedilol exposure. Both drugs can cause hypotension, so additive blood pressure lowering and orthostatic symptoms are possible.
What this interaction means in plain words
Carvedilol and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Haloperidol belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by haloperidol reduces carvedilol metabolism, with additive alpha-blocking hypotensive effects.
What to do
Monitor blood pressure, including orthostatic readings, and heart rate when combining the two. Reduce the carvedilol dose if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Carvedilol with Haloperidol?
MediHelp rates the interaction as moderate. Carvedilol and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol inhibits CYP2D6 to a modest degree and may increase carvedilol exposure. Both drugs can cause hypotension, so additive blood pressure lowering and orthostatic symptoms are possible.
How serious is the interaction between Carvedilol and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including orthostatic readings, and heart rate when combining the two. Reduce the carvedilol dose if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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