Drug interactions
Carvedilol + Hydrochlorothiazide-lisinopril
Severity: Minor
Carvedilol and Hydrochlorothiazide-lisinopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol has alpha-blocking vasodilating activity that adds to the blood pressure lowering of lisinopril and hydrochlorothiazide, with a risk of hypotension and dizziness. Thiazides can also modestly worsen glucose control.
What this interaction means in plain words
Carvedilol and Hydrochlorothiazide-lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects of beta and alpha blockade, ACE inhibition and diuresis.
What to do
Monitor blood pressure and heart rate, and advise slow position changes. Adjust doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as minor. Carvedilol and Hydrochlorothiazide-lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carvedilol has alpha-blocking vasodilating activity that adds to the blood pressure lowering of lisinopril and hydrochlorothiazide, with a risk of hypotension and dizziness. Thiazides can also modestly worsen glucose control.
How serious is the interaction between Carvedilol and Hydrochlorothiazide-lisinopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and advise slow position changes. Adjust doses if symptomatic hypotension occurs.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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