Drug interactions
Carvedilol + Ivabradine
Severity: Moderate
Carvedilol and Ivabradine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower heart rate, and together they raise the risk of symptomatic bradycardia and conduction disturbances. The combination is used in heart failure but requires attention to heart rate.
What this interaction means in plain words
Carvedilol and Ivabradine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Ivabradine belongs to Cardiovascular.
Why it happens
Additive heart rate lowering from sinus node If-current inhibition and beta-adrenergic blockade.
What to do
Monitor heart rate and symptoms during initiation and titration of either drug. Reduce the dose or stop ivabradine if resting heart rate falls persistently below the labeled threshold or symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Frequently asked questions
Can I take Carvedilol with Ivabradine?
MediHelp rates the interaction as moderate. Carvedilol and Ivabradine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower heart rate, and together they raise the risk of symptomatic bradycardia and conduction disturbances. The combination is used in heart failure but requires attention to heart rate.
How serious is the interaction between Carvedilol and Ivabradine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and symptoms during initiation and titration of either drug. Reduce the dose or stop ivabradine if resting heart rate falls persistently below the labeled threshold or symptoms appear.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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