Drug interactions
Carvedilol + Ivacaftor
Severity: Minor
Carvedilol and Ivacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor weakly inhibits P-glycoprotein and may modestly increase exposure to P-gp substrates such as carvedilol. This is unlikely to cause problems in most patients, but bradycardia or hypotension is possible.
What this interaction means in plain words
Carvedilol and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Ivacaftor belongs to Miscellaneous.
Why it happens
Ivacaftor and its M1 metabolite weakly inhibit P-gp efflux of carvedilol.
What to do
Usually no dose change is needed. Monitor heart rate and blood pressure after ivacaftor is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carvedilol
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Carvedilol with Ivacaftor?
MediHelp rates the interaction as minor. Carvedilol and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor weakly inhibits P-glycoprotein and may modestly increase exposure to P-gp substrates such as carvedilol. This is unlikely to cause problems in most patients, but bradycardia or hypotension is possible.
How serious is the interaction between Carvedilol and Ivacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no dose change is needed. Monitor heart rate and blood pressure after ivacaftor is started.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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