Drug interactions
Carvedilol + Labetalol
Severity: Major
Carvedilol and Labetalol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are combined alpha- and beta-adrenergic blockers, so using them together duplicates therapy. This increases the risk of hypotension, bradycardia, dizziness and fatigue without a clear added benefit.
What this interaction means in plain words
Carvedilol and Labetalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carvedilol belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Therapeutic duplication with additive alpha-1 and beta-adrenergic receptor blockade.
What to do
Avoid using two combined alpha/beta blockers together; choose a single agent and titrate it. If a transition is made, stop one drug before starting the other and monitor heart rate and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carvedilol and Labetalol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Labetalol?
MediHelp rates the interaction as major. Carvedilol and Labetalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are combined alpha- and beta-adrenergic blockers, so using them together duplicates therapy. This increases the risk of hypotension, bradycardia, dizziness and fatigue without a clear added benefit.
How serious is the interaction between Carvedilol and Labetalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two combined alpha/beta blockers together; choose a single agent and titrate it. If a transition is made, stop one drug before starting the other and monitor heart rate and blood pressure.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
