Drug interactions
Carvedilol + Lomitapide
Severity: Moderate
Carvedilol and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide inhibits P-glycoprotein and may raise carvedilol exposure. This could increase carvedilol-related hypotension and bradycardia.
What this interaction means in plain words
Carvedilol and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Lomitapide belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein-mediated efflux of carvedilol by lomitapide.
What to do
Monitor blood pressure and heart rate and consider reducing the carvedilol dose when lomitapide is started.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Carvedilol with Lomitapide?
MediHelp rates the interaction as moderate. Carvedilol and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide inhibits P-glycoprotein and may raise carvedilol exposure. This could increase carvedilol-related hypotension and bradycardia.
How serious is the interaction between Carvedilol and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and consider reducing the carvedilol dose when lomitapide is started.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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