Drug interactions
Carvedilol + Losartan
Severity: Moderate
Carvedilol and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs reduce blood pressure, so the combination gives additive hypotension and is often used intentionally in hypertension and heart failure. Losartan can increase serum potassium and affect renal function, and beta-blockade can slightly add to this tendency.
What this interaction means in plain words
Carvedilol and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Losartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects, with reduced aldosterone-mediated potassium excretion by losartan and impaired cellular potassium uptake with beta-blockade.
What to do
Monitor blood pressure, serum potassium and creatinine after starting or changing doses. Avoid unneeded potassium supplements.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carvedilol and Losartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Carvedilol
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Carvedilol with Losartan?
MediHelp rates the interaction as moderate. Carvedilol and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs reduce blood pressure, so the combination gives additive hypotension and is often used intentionally in hypertension and heart failure. Losartan can increase serum potassium and affect renal function, and beta-blockade can slightly add to this tendency.
How serious is the interaction between Carvedilol and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and creatinine after starting or changing doses. Avoid unneeded potassium supplements.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
