Drug interactions
Carvedilol + Lurasidone
Severity: Moderate
Carvedilol and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone has alpha-1 adrenergic blocking activity that can cause orthostatic hypotension, and this adds to the vasodilating effects of carvedilol. Dizziness, syncope and falls are the main concerns, especially at initiation or dose increases.
What this interaction means in plain words
Carvedilol and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Lurasidone belongs to Central Nervous System.
Why it happens
Additive alpha-1 adrenergic antagonism and blood pressure lowering.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing either drug. Reduce the antihypertensive dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carvedilol and Lurasidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Carvedilol
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Carvedilol with Lurasidone?
MediHelp rates the interaction as moderate. Carvedilol and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone has alpha-1 adrenergic blocking activity that can cause orthostatic hypotension, and this adds to the vasodilating effects of carvedilol. Dizziness, syncope and falls are the main concerns, especially at initiation or dose increases.
How serious is the interaction between Carvedilol and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing either drug. Reduce the antihypertensive dose if hypotension develops.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
