Drug interactions
Carvedilol + Mefenamic acid
Severity: Moderate
Carvedilol and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prolonged NSAID use can reduce the antihypertensive effect of carvedilol and may worsen fluid retention in heart failure.
What this interaction means in plain words
Carvedilol and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Mefenamic acid belongs to Musculoskeletal.
Why it happens
NSAID-mediated prostaglandin inhibition causes sodium and water retention and vasoconstriction, opposing the beta-blocker.
What to do
Monitor blood pressure, weight and heart failure symptoms during prolonged NSAID use and adjust therapy if needed. Use the lowest effective NSAID dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Mefenamic acid?
MediHelp rates the interaction as moderate. Carvedilol and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prolonged NSAID use can reduce the antihypertensive effect of carvedilol and may worsen fluid retention in heart failure.
How serious is the interaction between Carvedilol and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, weight and heart failure symptoms during prolonged NSAID use and adjust therapy if needed. Use the lowest effective NSAID dose.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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