Drug interactions
Carvedilol + Nisoldipine
Severity: Moderate
Carvedilol and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure, so combined use can lead to additive hypotension and dizziness. Reflex tachycardia from nisoldipine may be blunted by carvedilol.
What this interaction means in plain words
Carvedilol and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Nisoldipine belongs to Cardiovascular.
Why it happens
Additive vasodilation from calcium channel blockade and alpha/beta-adrenergic blockade.
What to do
Monitor blood pressure and heart rate during initiation and dose changes, and adjust doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Carvedilol with Nisoldipine?
MediHelp rates the interaction as moderate. Carvedilol and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure, so combined use can lead to additive hypotension and dizziness. Reflex tachycardia from nisoldipine may be blunted by carvedilol.
How serious is the interaction between Carvedilol and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during initiation and dose changes, and adjust doses as needed.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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