Drug interactions
Carvedilol + Perphenazine
Severity: Moderate
Carvedilol and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine is a substrate and inhibitor of CYP2D6 and may raise carvedilol concentrations. Both drugs can lower blood pressure, so additive hypotension and orthostatic symptoms are possible.
What this interaction means in plain words
Carvedilol and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Perphenazine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by perphenazine reduces carvedilol metabolism, with additive alpha-blocking hypotensive effects.
What to do
Monitor blood pressure including orthostatic readings and heart rate. Reduce the carvedilol dose if symptomatic hypotension or bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Carvedilol with Perphenazine?
MediHelp rates the interaction as moderate. Carvedilol and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine is a substrate and inhibitor of CYP2D6 and may raise carvedilol concentrations. Both drugs can lower blood pressure, so additive hypotension and orthostatic symptoms are possible.
How serious is the interaction between Carvedilol and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including orthostatic readings and heart rate. Reduce the carvedilol dose if symptomatic hypotension or bradycardia develops.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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