Drug interactions
Carvedilol + Rimegepant
Severity: Moderate
Carvedilol and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol may inhibit intestinal P-glycoprotein and increase rimegepant exposure. The clinical effect is expected to be modest.
What this interaction means in plain words
Carvedilol and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Rimegepant belongs to Central Nervous System.
Why it happens
Inhibition of P-glycoprotein efflux of rimegepant by carvedilol.
What to do
Avoid a second rimegepant dose within 48 hours when taken with a P-gp inhibitor, per labeling. Monitor for adverse effects such as nausea.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Rimegepant
Frequently asked questions
Can I take Carvedilol with Rimegepant?
MediHelp rates the interaction as moderate. Carvedilol and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carvedilol may inhibit intestinal P-glycoprotein and increase rimegepant exposure. The clinical effect is expected to be modest.
How serious is the interaction between Carvedilol and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid a second rimegepant dose within 48 hours when taken with a P-gp inhibitor, per labeling. Monitor for adverse effects such as nausea.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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