Drug interactions
Carvedilol + Tipranavir
Severity: Moderate
Carvedilol and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, may inhibit CYP2D6 and raise carvedilol concentrations. This may cause bradycardia and hypotension.
What this interaction means in plain words
Carvedilol and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Tipranavir belongs to Anti Virals.
Why it happens
Inhibition of CYP2D6 (and possibly P-gp) reduces carvedilol clearance.
What to do
Monitor heart rate and blood pressure and reduce the carvedilol dose if excessive beta-blockade occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Carvedilol with Tipranavir?
MediHelp rates the interaction as moderate. Carvedilol and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir, given with ritonavir, may inhibit CYP2D6 and raise carvedilol concentrations. This may cause bradycardia and hypotension.
How serious is the interaction between Carvedilol and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and reduce the carvedilol dose if excessive beta-blockade occurs.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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