Drug interactions
Cefaclor + Streptomycin
Severity: Minor
Cefaclor and Streptomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefaclor given with streptomycin may add to the risk of kidney injury, particularly in patients with renal impairment or dehydration. Streptomycin is the main source of renal and vestibular or cochlear toxicity, and reduced renal function raises its exposure.
What this interaction means in plain words
Cefaclor and Streptomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefaclor belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.
Why it happens
Possible additive nephrotoxic potential; evidence for cefaclor is weak.
What to do
Monitor renal function and streptomycin levels, and assess hearing and balance. Adjust the streptomycin dose for renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefaclor
- Bcg vaccine live + Cefaclor Moderate
- Cefaclor + Cholera vaccine Moderate
- Cefaclor + Kanamycin Moderate
- Cefaclor + Microbiota Moderate
- Cefaclor + Plazomicin Moderate
- Cefaclor + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Other interactions of Streptomycin
Frequently asked questions
Can I take Cefaclor with Streptomycin?
MediHelp rates the interaction as minor. Cefaclor and Streptomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cefaclor given with streptomycin may add to the risk of kidney injury, particularly in patients with renal impairment or dehydration. Streptomycin is the main source of renal and vestibular or cochlear toxicity, and reduced renal function raises its exposure.
How serious is the interaction between Cefaclor and Streptomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and streptomycin levels, and assess hearing and balance. Adjust the streptomycin dose for renal function.
What other medicines interact with Cefaclor?
MediHelp also lists interactions of Cefaclor with, for example, Bcg vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefaclor page.
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