Drug interactions
Cefaclor + Tobramycin
Severity: Minor
Cefaclor and Tobramycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefaclor given with tobramycin may add to the risk of kidney injury, particularly in patients with renal impairment or dehydration. Tobramycin is the main nephrotoxic and ototoxic agent, and oral cefaclor contributes little.
What this interaction means in plain words
Cefaclor and Tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefaclor belongs to Anti Bacterial; Tobramycin belongs to Anti Bacterial.
Why it happens
Possible additive nephrotoxic potential; evidence for cefaclor is weak.
What to do
Monitor serum creatinine and tobramycin trough levels during therapy. Adjust the tobramycin dose for renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefaclor
- Bcg vaccine live + Cefaclor Moderate
- Cefaclor + Cholera vaccine Moderate
- Cefaclor + Kanamycin Moderate
- Cefaclor + Microbiota Moderate
- Cefaclor + Plazomicin Moderate
- Cefaclor + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Cefaclor with Tobramycin?
MediHelp rates the interaction as minor. Cefaclor and Tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cefaclor given with tobramycin may add to the risk of kidney injury, particularly in patients with renal impairment or dehydration. Tobramycin is the main nephrotoxic and ototoxic agent, and oral cefaclor contributes little.
How serious is the interaction between Cefaclor and Tobramycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and tobramycin trough levels during therapy. Adjust the tobramycin dose for renal function.
What other medicines interact with Cefaclor?
MediHelp also lists interactions of Cefaclor with, for example, Bcg vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefaclor page.
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