Drug interactions
Cefadroxil + Chloramphenicol
Severity: Minor
Cefadroxil and Chloramphenicol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol is bacteriostatic and may blunt the bactericidal activity of beta-lactams such as cefadroxil. The clinical importance is uncertain and is mainly a concern in serious infections. Documented evidence in humans is limited.
What this interaction means in plain words
Cefadroxil and Chloramphenicol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefadroxil belongs to Anti Bacterial; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Bacteriostatic inhibition of protein synthesis may reduce the killing of actively dividing bacteria that beta-lactams depend on.
What to do
Avoid combining where possible in serious infections such as meningitis or endocarditis, and choose a single suitable agent. Monitor clinical response if both are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefadroxil
- Amikacin + Cefadroxil Moderate
- Avelumab + Cefadroxil Moderate
- Balstilimab + Cefadroxil Moderate
- Bcg vaccine live + Cefadroxil Moderate
- Cefadroxil + Cholera vaccine Moderate
- Cefadroxil + Gentamicin Moderate
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Cefadroxil with Chloramphenicol?
MediHelp rates the interaction as minor. Cefadroxil and Chloramphenicol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloramphenicol is bacteriostatic and may blunt the bactericidal activity of beta-lactams such as cefadroxil. The clinical importance is uncertain and is mainly a concern in serious infections. Documented evidence in humans is limited.
How serious is the interaction between Cefadroxil and Chloramphenicol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible in serious infections such as meningitis or endocarditis, and choose a single suitable agent. Monitor clinical response if both are used.
What other medicines interact with Cefadroxil?
MediHelp also lists interactions of Cefadroxil with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefadroxil page.
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