Drug interactions
Cefadroxil + Diclofenac
Severity: Minor
Cefadroxil and Diclofenac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are organic anion substrates secreted by renal tubules, so competition could slightly alter their clearance. No clinically meaningful effect is expected in most patients.
What this interaction means in plain words
Cefadroxil and Diclofenac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefadroxil belongs to Anti Bacterial; Diclofenac belongs to Musculoskeletal.
Why it happens
Theoretical competition for renal tubular anion transport.
What to do
No action is generally needed; monitor renal function if the patient has renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Cefadroxil
- Amikacin + Cefadroxil Moderate
- Avelumab + Cefadroxil Moderate
- Balstilimab + Cefadroxil Moderate
- Bcg vaccine live + Cefadroxil Moderate
- Cefadroxil + Cholera vaccine Moderate
- Cefadroxil + Gentamicin Moderate
Frequently asked questions
Can I take Cefadroxil with Diclofenac?
MediHelp rates the interaction as minor. Cefadroxil and Diclofenac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are organic anion substrates secreted by renal tubules, so competition could slightly alter their clearance. No clinically meaningful effect is expected in most patients.
How serious is the interaction between Cefadroxil and Diclofenac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed; monitor renal function if the patient has renal impairment.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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