Drug interactions
Cefadroxil + Indomethacin
Severity: Minor
Cefadroxil and Indomethacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are organic acids eliminated partly by renal tubular secretion, so they may compete for the same transporters. Indomethacin exposure could rise slightly, but the clinical effect is generally small and unproven.
What this interaction means in plain words
Cefadroxil and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefadroxil belongs to Anti Bacterial; Indomethacin belongs to Musculoskeletal.
Why it happens
Possible competition for renal organic anion transporter-mediated tubular secretion.
What to do
No routine action is needed; watch for increased NSAID adverse effects such as GI upset or renal changes if both are used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Cefadroxil
- Amikacin + Cefadroxil Moderate
- Avelumab + Cefadroxil Moderate
- Balstilimab + Cefadroxil Moderate
- Bcg vaccine live + Cefadroxil Moderate
- Cefadroxil + Cholera vaccine Moderate
- Cefadroxil + Gentamicin Moderate
Frequently asked questions
Can I take Cefadroxil with Indomethacin?
MediHelp rates the interaction as minor. Cefadroxil and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are organic acids eliminated partly by renal tubular secretion, so they may compete for the same transporters. Indomethacin exposure could rise slightly, but the clinical effect is generally small and unproven.
How serious is the interaction between Cefadroxil and Indomethacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; watch for increased NSAID adverse effects such as GI upset or renal changes if both are used long term.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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