Drug interactions
Cefadroxil + Pivmecillinam
Severity: Minor
Cefadroxil and Pivmecillinam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are beta-lactam antibiotics eliminated by the kidney through tubular secretion, so they could modestly compete for clearance. No clinically significant effect has been documented, and the combination is generally unnecessary rather than harmful. Any rise in levels is unlikely to be important at usual doses.
What this interaction means in plain words
Cefadroxil and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefadroxil belongs to Anti Bacterial; Pivmecillinam belongs to Anti Bacterial.
Why it happens
Possible competition for renal tubular secretion of beta-lactams via organic anion transporters.
What to do
No action is generally needed. Adjust doses for renal impairment as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefadroxil
- Amikacin + Cefadroxil Moderate
- Avelumab + Cefadroxil Moderate
- Balstilimab + Cefadroxil Moderate
- Bcg vaccine live + Cefadroxil Moderate
- Cefadroxil + Cholera vaccine Moderate
- Cefadroxil + Gentamicin Moderate
Other interactions of Pivmecillinam
- Doxycycline + Pivmecillinam Moderate
- Minocycline + Pivmecillinam Moderate
- Pivmecillinam + Probenecid Moderate
- Pivmecillinam + Tetracycline Moderate
- Acetylsalicylic acid + Pivmecillinam Minor
- Acyclovir + Pivmecillinam Minor
Frequently asked questions
Can I take Cefadroxil with Pivmecillinam?
MediHelp rates the interaction as minor. Cefadroxil and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both are beta-lactam antibiotics eliminated by the kidney through tubular secretion, so they could modestly compete for clearance. No clinically significant effect has been documented, and the combination is generally unnecessary rather than harmful. Any rise in levels is unlikely to be important at usual doses.
How serious is the interaction between Cefadroxil and Pivmecillinam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed. Adjust doses for renal impairment as usual.
What other medicines interact with Cefadroxil?
MediHelp also lists interactions of Cefadroxil with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefadroxil page.
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