Drug interactions
Cefadroxil + Probenecid
Severity: Minor
Cefadroxil and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid slows renal elimination of cefadroxil, producing higher and longer-lasting concentrations. This is usually of little clinical concern given the wide safety margin of cephalosporins.
What this interaction means in plain words
Cefadroxil and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefadroxil belongs to Anti Bacterial; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits tubular secretion of cefadroxil via organic anion transporters.
What to do
No routine adjustment is required; consider monitoring in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Cefadroxil
- Amikacin + Cefadroxil Moderate
- Avelumab + Cefadroxil Moderate
- Balstilimab + Cefadroxil Moderate
- Bcg vaccine live + Cefadroxil Moderate
- Cefadroxil + Cholera vaccine Moderate
- Cefadroxil + Gentamicin Moderate
Frequently asked questions
Can I take Cefadroxil with Probenecid?
MediHelp rates the interaction as minor. Cefadroxil and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Probenecid slows renal elimination of cefadroxil, producing higher and longer-lasting concentrations. This is usually of little clinical concern given the wide safety margin of cephalosporins.
How serious is the interaction between Cefadroxil and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; consider monitoring in patients with renal impairment.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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