Drug interactions
Cefadroxil + Sulindac
Severity: Minor
Cefadroxil and Sulindac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefadroxil and sulindac metabolites are both renally secreted by anion transport, so cefadroxil may slightly reduce sulindac clearance. The clinical impact is expected to be small.
What this interaction means in plain words
Cefadroxil and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefadroxil belongs to Anti Bacterial; Sulindac belongs to Musculoskeletal.
Why it happens
Possible competition for renal tubular secretion via organic anion transporters.
What to do
No dose adjustment is usually needed. Watch for increased NSAID adverse effects in patients with impaired renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Cefadroxil
- Amikacin + Cefadroxil Moderate
- Avelumab + Cefadroxil Moderate
- Balstilimab + Cefadroxil Moderate
- Bcg vaccine live + Cefadroxil Moderate
- Cefadroxil + Cholera vaccine Moderate
- Cefadroxil + Gentamicin Moderate
Frequently asked questions
Can I take Cefadroxil with Sulindac?
MediHelp rates the interaction as minor. Cefadroxil and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cefadroxil and sulindac metabolites are both renally secreted by anion transport, so cefadroxil may slightly reduce sulindac clearance. The clinical impact is expected to be small.
How serious is the interaction between Cefadroxil and Sulindac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Watch for increased NSAID adverse effects in patients with impaired renal function.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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