Drug interactions
Cefadroxil + Warfarin
Severity: Moderate
Cefadroxil and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalosporins can occasionally raise INR and bleeding risk in patients taking warfarin, particularly during acute infection. The effect varies between patients and is generally modest with cefadroxil.
What this interaction means in plain words
Cefadroxil and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefadroxil belongs to Anti Bacterial; Warfarin belongs to Cardiovascular.
Why it happens
Probable reduction of vitamin K-producing gut flora, with possible additional effects of infection on warfarin response; not fully established.
What to do
Check INR within a few days of starting cefadroxil and adjust the warfarin dose as needed. Counsel the patient to report bleeding or bruising.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefadroxil
- Amikacin + Cefadroxil Moderate
- Avelumab + Cefadroxil Moderate
- Balstilimab + Cefadroxil Moderate
- Bcg vaccine live + Cefadroxil Moderate
- Cefadroxil + Cholera vaccine Moderate
- Cefadroxil + Gentamicin Moderate
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Cefadroxil with Warfarin?
MediHelp rates the interaction as moderate. Cefadroxil and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalosporins can occasionally raise INR and bleeding risk in patients taking warfarin, particularly during acute infection. The effect varies between patients and is generally modest with cefadroxil.
How serious is the interaction between Cefadroxil and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR within a few days of starting cefadroxil and adjust the warfarin dose as needed. Counsel the patient to report bleeding or bruising.
What other medicines interact with Cefadroxil?
MediHelp also lists interactions of Cefadroxil with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefadroxil page.
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