Drug interactions
Cefalexin + Plazomicin
Severity: Moderate
Cefalexin and Plazomicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Plazomicin is an aminoglycoside with labeled risks of nephrotoxicity and ototoxicity. Other agents that can impair renal function, including cephalosporins in some reports, may add to kidney injury and raise plazomicin exposure.
What this interaction means in plain words
Cefalexin and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefalexin belongs to Anti Bacterial; Plazomicin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxic potential, with reduced renal clearance increasing aminoglycoside accumulation and ototoxicity.
What to do
Monitor serum creatinine and plazomicin concentrations, and adjust dosing to renal function per labeling. Watch for hearing loss, tinnitus or vestibular symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefalexin
- Amikacin + Cefalexin Moderate
- Avelumab + Cefalexin Moderate
- Balstilimab + Cefalexin Moderate
- Bcg vaccine live + Cefalexin Moderate
- Cefalexin + Cholera vaccine Moderate
- Cefalexin + Gentamicin Moderate
Other interactions of Plazomicin
- Cefaclor + Plazomicin Moderate
- Cefadroxil + Plazomicin Moderate
- Cefazolin + Plazomicin Moderate
- Cefditoren + Plazomicin Moderate
- Cefepime + Plazomicin Moderate
- Cefixime + Plazomicin Moderate
Frequently asked questions
Can I take Cefalexin with Plazomicin?
MediHelp rates the interaction as moderate. Cefalexin and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Plazomicin is an aminoglycoside with labeled risks of nephrotoxicity and ototoxicity. Other agents that can impair renal function, including cephalosporins in some reports, may add to kidney injury and raise plazomicin exposure.
How serious is the interaction between Cefalexin and Plazomicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and plazomicin concentrations, and adjust dosing to renal function per labeling. Watch for hearing loss, tinnitus or vestibular symptoms.
What other medicines interact with Cefalexin?
MediHelp also lists interactions of Cefalexin with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefalexin page.
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