Drug interactions
Cefazolin + Plazomicin
Severity: Moderate
Cefazolin and Plazomicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefazolin given with plazomicin may add to the risk of kidney injury, and plazomicin carries its own risk of nephrotoxicity, ototoxicity and neuromuscular blockade. Impaired renal function would increase plazomicin exposure and toxicity.
What this interaction means in plain words
Cefazolin and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefazolin belongs to Anti Bacterial; Plazomicin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxic potential, with reduced aminoglycoside clearance if renal function declines.
What to do
Monitor serum creatinine and plazomicin concentrations during combined use. Adjust the plazomicin dose to renal function and monitor for hearing or balance changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefazolin
- Amikacin + Cefazolin Moderate
- Bcg vaccine live + Cefazolin Moderate
- Cefazolin + Cholera vaccine Moderate
- Cefazolin + Dexamethasone-tobramycin Moderate
- Cefazolin + Gentamicin Moderate
- Cefazolin + Kanamycin Moderate
Other interactions of Plazomicin
- Cefaclor + Plazomicin Moderate
- Cefadroxil + Plazomicin Moderate
- Cefalexin + Plazomicin Moderate
- Cefditoren + Plazomicin Moderate
- Cefepime + Plazomicin Moderate
- Cefixime + Plazomicin Moderate
Frequently asked questions
Can I take Cefazolin with Plazomicin?
MediHelp rates the interaction as moderate. Cefazolin and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefazolin given with plazomicin may add to the risk of kidney injury, and plazomicin carries its own risk of nephrotoxicity, ototoxicity and neuromuscular blockade. Impaired renal function would increase plazomicin exposure and toxicity.
How serious is the interaction between Cefazolin and Plazomicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and plazomicin concentrations during combined use. Adjust the plazomicin dose to renal function and monitor for hearing or balance changes.
What other medicines interact with Cefazolin?
MediHelp also lists interactions of Cefazolin with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefazolin page.
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