Drug interactions
Cefamandole + Dalteparin
Severity: Moderate
Cefamandole and Dalteparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefamandole can impair vitamin K-dependent clotting factor synthesis and platelet function, which may add to the anticoagulant effect of dalteparin. Bleeding risk may rise, particularly in malnourished, elderly or renally impaired patients.
What this interaction means in plain words
Cefamandole and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic effects: the N-methylthiotetrazole side chain of cefamandole causes hypoprothrombinemia and platelet dysfunction.
What to do
Monitor for bleeding and consider coagulation tests (PT/INR) and platelet count during co-therapy; give vitamin K if hypoprothrombinemia develops, or choose a cephalosporin without this side chain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Cefamandole with Dalteparin?
MediHelp rates the interaction as moderate. Cefamandole and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefamandole can impair vitamin K-dependent clotting factor synthesis and platelet function, which may add to the anticoagulant effect of dalteparin. Bleeding risk may rise, particularly in malnourished, elderly or renally impaired patients.
How serious is the interaction between Cefamandole and Dalteparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider coagulation tests (PT/INR) and platelet count during co-therapy; give vitamin K if hypoprothrombinemia develops, or choose a cephalosporin without this side chain.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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