Drug interactions
Cefamandole + Fondaparinux
Severity: Moderate
Cefamandole and Fondaparinux: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefamandole has an N-methylthiotetrazole side chain that can cause hypoprothrombinemia and impair platelet function. With fondaparinux this may increase bleeding risk.
What this interaction means in plain words
Cefamandole and Fondaparinux can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive bleeding tendency from vitamin K-dependent clotting factor reduction and platelet effects combined with factor Xa inhibition.
What to do
Monitor for bleeding and consider coagulation tests such as INR. Use vitamin K if hypoprothrombinemia develops, or choose another antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Frequently asked questions
Can I take Cefamandole with Fondaparinux?
MediHelp rates the interaction as moderate. Cefamandole and Fondaparinux can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefamandole has an N-methylthiotetrazole side chain that can cause hypoprothrombinemia and impair platelet function. With fondaparinux this may increase bleeding risk.
How serious is the interaction between Cefamandole and Fondaparinux?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider coagulation tests such as INR. Use vitamin K if hypoprothrombinemia develops, or choose another antibiotic.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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