Drug interactions
Cefdinir + Erythromycin base
Severity: Minor
Cefdinir and Erythromycin base: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin is a bacteriostatic macrolide and cefdinir is a bactericidal beta-lactam, so antagonism is theoretically possible. Clinically significant loss of cefdinir efficacy has not been well demonstrated, particularly in mild infections.
What this interaction means in plain words
Cefdinir and Erythromycin base have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical pharmacodynamic antagonism between a bacteriostatic and a bactericidal antibiotic.
What to do
Avoid unnecessary dual antibiotic therapy and use the single agent best matched to the pathogen. If combined, such as for atypical coverage, monitor clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefdinir
- Aluminum hydroxide + Cefdinir Moderate
- Cefdinir + Cholera vaccine Moderate
- Cefdinir + Famotidine Moderate
- Cefdinir + Gentamicin Moderate
- Cefdinir + Microbiota Moderate
- Cefdinir + Nizatidine Moderate
Frequently asked questions
Can I take Cefdinir with Erythromycin base?
MediHelp rates the interaction as minor. Cefdinir and Erythromycin base have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin is a bacteriostatic macrolide and cefdinir is a bactericidal beta-lactam, so antagonism is theoretically possible. Clinically significant loss of cefdinir efficacy has not been well demonstrated, particularly in mild infections.
How serious is the interaction between Cefdinir and Erythromycin base?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary dual antibiotic therapy and use the single agent best matched to the pathogen. If combined, such as for atypical coverage, monitor clinical response.
What other medicines interact with Cefdinir?
MediHelp also lists interactions of Cefdinir with, for example, Aluminum hydroxide, Cholera vaccine, Famotidine. The full list is on the Cefdinir page.
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