Drug interactions
Cefdinir + Famotidine
Severity: Moderate
Cefdinir and Famotidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Acid-reducing agents lower cefdinir absorption, which may reduce antibiotic exposure and efficacy. Famotidine has been shown to decrease cefdinir exposure.
What this interaction means in plain words
Cefdinir and Famotidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefdinir belongs to Anti Bacterial; Famotidine belongs to Gastrointestinal Tract.
Why it happens
Increased gastric pH reduces cefdinir absorption.
What to do
Consider avoiding the H2 blocker during the antibiotic course. If it is required, monitor clinical response to the infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Famotidine
Other interactions of Cefdinir
- Aluminum hydroxide + Cefdinir Moderate
- Cefdinir + Cholera vaccine Moderate
- Cefdinir + Gentamicin Moderate
- Cefdinir + Microbiota Moderate
- Cefdinir + Nizatidine Moderate
- Cefdinir + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Frequently asked questions
Can I take Cefdinir with Famotidine?
MediHelp rates the interaction as moderate. Cefdinir and Famotidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Acid-reducing agents lower cefdinir absorption, which may reduce antibiotic exposure and efficacy. Famotidine has been shown to decrease cefdinir exposure.
How serious is the interaction between Cefdinir and Famotidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider avoiding the H2 blocker during the antibiotic course. If it is required, monitor clinical response to the infection.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
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