Drug interactions
Cefdinir + Gentamicin
Severity: Moderate
Cefdinir and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalosporins have been reported to add to aminoglycoside nephrotoxicity, though oral cefdinir has low direct renal toxicity. Risk is higher in patients with kidney impairment, older age, or dehydration.
What this interaction means in plain words
Cefdinir and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefdinir belongs to Anti Bacterial; Gentamicin belongs to Anti Bacterial.
Why it happens
Possible additive renal tubular injury; cefdinir itself is rarely nephrotoxic.
What to do
Monitor serum creatinine and gentamicin levels during co-therapy, and adjust gentamicin dosing to renal function. Maintain hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefdinir
- Aluminum hydroxide + Cefdinir Moderate
- Cefdinir + Cholera vaccine Moderate
- Cefdinir + Famotidine Moderate
- Cefdinir + Microbiota Moderate
- Cefdinir + Nizatidine Moderate
- Cefdinir + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Cefdinir with Gentamicin?
MediHelp rates the interaction as moderate. Cefdinir and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalosporins have been reported to add to aminoglycoside nephrotoxicity, though oral cefdinir has low direct renal toxicity. Risk is higher in patients with kidney impairment, older age, or dehydration.
How serious is the interaction between Cefdinir and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin levels during co-therapy, and adjust gentamicin dosing to renal function. Maintain hydration.
What other medicines interact with Cefdinir?
MediHelp also lists interactions of Cefdinir with, for example, Aluminum hydroxide, Cholera vaccine, Famotidine. The full list is on the Cefdinir page.
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