Drug interactions
Cefdinir + Ibuprofen / famotidine
Severity: Minor
Cefdinir and Ibuprofen / famotidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine raises gastric pH, which can reduce the absorption of oral cefdinir. This may lower cefdinir exposure and could reduce its efficacy in some infections. Ibuprofen does not contribute to this effect.
What this interaction means in plain words
Cefdinir and Ibuprofen / famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Higher gastric pH from the H2 antagonist reduces cefdinir absorption.
What to do
Be aware of potential reduced cefdinir response, and consider an alternative antibiotic if treating a serious infection. Monitor clinical response to therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefdinir
- Aluminum hydroxide + Cefdinir Moderate
- Cefdinir + Cholera vaccine Moderate
- Cefdinir + Famotidine Moderate
- Cefdinir + Gentamicin Moderate
- Cefdinir + Microbiota Moderate
- Cefdinir + Nizatidine Moderate
Frequently asked questions
Can I take Cefdinir with Ibuprofen / famotidine?
MediHelp rates the interaction as minor. Cefdinir and Ibuprofen / famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine raises gastric pH, which can reduce the absorption of oral cefdinir. This may lower cefdinir exposure and could reduce its efficacy in some infections. Ibuprofen does not contribute to this effect.
How serious is the interaction between Cefdinir and Ibuprofen / famotidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware of potential reduced cefdinir response, and consider an alternative antibiotic if treating a serious infection. Monitor clinical response to therapy.
What other medicines interact with Cefdinir?
MediHelp also lists interactions of Cefdinir with, for example, Aluminum hydroxide, Cholera vaccine, Famotidine. The full list is on the Cefdinir page.
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