Drug interactions
Cefdinir + Kanamycin
Severity: Minor
Cefdinir and Kanamycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalosporins given with aminoglycosides have been associated with additive kidney injury in some reports. Cefdinir is oral and rarely nephrotoxic, so the added risk is modest, but kanamycin itself carries nephrotoxicity and ototoxicity risk.
What this interaction means in plain words
Cefdinir and Kanamycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive nephrotoxicity; the mechanism is not well established for cefdinir.
What to do
Monitor serum creatinine and aminoglycoside levels during kanamycin therapy. Adjust the kanamycin dose to renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefdinir
- Aluminum hydroxide + Cefdinir Moderate
- Cefdinir + Cholera vaccine Moderate
- Cefdinir + Famotidine Moderate
- Cefdinir + Gentamicin Moderate
- Cefdinir + Microbiota Moderate
- Cefdinir + Nizatidine Moderate
Frequently asked questions
Can I take Cefdinir with Kanamycin?
MediHelp rates the interaction as minor. Cefdinir and Kanamycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cephalosporins given with aminoglycosides have been associated with additive kidney injury in some reports. Cefdinir is oral and rarely nephrotoxic, so the added risk is modest, but kanamycin itself carries nephrotoxicity and ototoxicity risk.
How serious is the interaction between Cefdinir and Kanamycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and aminoglycoside levels during kanamycin therapy. Adjust the kanamycin dose to renal function.
What other medicines interact with Cefdinir?
MediHelp also lists interactions of Cefdinir with, for example, Aluminum hydroxide, Cholera vaccine, Famotidine. The full list is on the Cefdinir page.
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