Drug interactions
Cefepime / enmetazobactam + Ethinyl estradiol-drospirenone
Severity: Minor
Cefepime / enmetazobactam and Ethinyl estradiol-drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
It has been proposed that antibacterials reduce enterohepatic recycling of ethinyl estradiol by altering gut flora. Evidence of reduced contraceptive efficacy with non-rifamycin antibiotics is limited. Any risk is considered low.
What this interaction means in plain words
Cefepime / enmetazobactam and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction in gut bacterial hydrolysis of estrogen conjugates, lowering enterohepatic recirculation of ethinyl estradiol.
What to do
No routine change is required. Advise backup contraception if vomiting or severe diarrhea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Cefepime / enmetazobactam with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as minor. Cefepime / enmetazobactam and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. It has been proposed that antibacterials reduce enterohepatic recycling of ethinyl estradiol by altering gut flora. Evidence of reduced contraceptive efficacy with non-rifamycin antibiotics is limited. Any risk is considered low.
How serious is the interaction between Cefepime / enmetazobactam and Ethinyl estradiol-drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is required. Advise backup contraception if vomiting or severe diarrhea occurs.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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