Drug interactions
Cefepime / enmetazobactam + Furosemide
Severity: Moderate
Cefepime / enmetazobactam and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics with cephalosporins have been associated with renal impairment mainly in volume-depleted or already compromised patients, though reports are inconsistent. Both are renally cleared and cefepime accumulation can cause neurotoxicity in renal impairment.
What this interaction means in plain words
Cefepime / enmetazobactam and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Diuretic-induced volume depletion and reduced renal clearance may increase beta-lactam exposure; direct nephrotoxic synergy is uncertain.
What to do
Monitor renal function and hydration status, and adjust cefepime/enmetazobactam dose to creatinine clearance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Cefepime / enmetazobactam with Furosemide?
MediHelp rates the interaction as moderate. Cefepime / enmetazobactam and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics with cephalosporins have been associated with renal impairment mainly in volume-depleted or already compromised patients, though reports are inconsistent. Both are renally cleared and cefepime accumulation can cause neurotoxicity in renal impairment.
How serious is the interaction between Cefepime / enmetazobactam and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and hydration status, and adjust cefepime/enmetazobactam dose to creatinine clearance.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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