Drug interactions
Cefepime / enmetazobactam + Gentamicin
Severity: Minor
Cefepime / enmetazobactam and Gentamicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefepime is not itself strongly nephrotoxic, and the combination with gentamicin is often used deliberately. Any added kidney risk is mainly related to the aminoglycoside and underlying illness, so the interaction is of limited significance.
What this interaction means in plain words
Cefepime / enmetazobactam and Gentamicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive renal stress; no well-established pharmacokinetic or direct toxic interaction.
What to do
Monitor renal function and adjust doses to renal function during combined therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Cefepime / enmetazobactam with Gentamicin?
MediHelp rates the interaction as minor. Cefepime / enmetazobactam and Gentamicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cefepime is not itself strongly nephrotoxic, and the combination with gentamicin is often used deliberately. Any added kidney risk is mainly related to the aminoglycoside and underlying illness, so the interaction is of limited significance.
How serious is the interaction between Cefepime / enmetazobactam and Gentamicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and adjust doses to renal function during combined therapy.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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