Drug interactions
Cefixime + Tobramycin
Severity: Minor
Cefixime and Tobramycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a cephalosporin with an aminoglycoside may raise the risk of kidney injury, and tobramycin itself is nephrotoxic and ototoxic. Oral cefixime is not notably nephrotoxic, so the added risk is small and mostly relevant in patients with renal impairment or other risk factors.
What this interaction means in plain words
Cefixime and Tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefixime belongs to Anti Bacterial; Tobramycin belongs to Anti Bacterial.
Why it happens
Possible additive nephrotoxicity, though not well established for oral cefixime.
What to do
Monitor serum creatinine and tobramycin levels as is routine for aminoglycoside therapy, and adjust the dose to renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefixime
- Cefixime + Typhoid vaccine live Major
- Cefixime + Cholera vaccine Moderate
- Cefixime + Kanamycin Moderate
- Cefixime + Microbiota Moderate
- Cefixime + Plazomicin Moderate
- Cefixime + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Cefixime with Tobramycin?
MediHelp rates the interaction as minor. Cefixime and Tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Combining a cephalosporin with an aminoglycoside may raise the risk of kidney injury, and tobramycin itself is nephrotoxic and ototoxic. Oral cefixime is not notably nephrotoxic, so the added risk is small and mostly relevant in patients with renal impairment or other risk factors.
How serious is the interaction between Cefixime and Tobramycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and tobramycin levels as is routine for aminoglycoside therapy, and adjust the dose to renal function.
What other medicines interact with Cefixime?
MediHelp also lists interactions of Cefixime with, for example, Typhoid vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefixime page.
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