Drug interactions
Cefotaxime + Voclosporin
Severity: Moderate
Cefotaxime and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor with dose-related nephrotoxicity, and cephalosporins such as cefotaxime may occasionally impair renal function. Concurrent use could add to the risk of kidney injury, especially in patients with lupus nephritis and reduced GFR.
What this interaction means in plain words
Cefotaxime and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefotaxime belongs to Anti Bacterial; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxic potential, with calcineurin-inhibitor renal vasoconstriction plus possible cephalosporin tubular effects.
What to do
Monitor serum creatinine and eGFR regularly during combined use and adjust voclosporin per labeling if renal function worsens. Dose cefotaxime according to renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefotaxime
- Cefotaxime + Typhoid vaccine live Major
- Amikacin + Cefotaxime Moderate
- Cefotaxime + Cholera vaccine Moderate
- Cefotaxime + Dexamethasone-tobramycin Moderate
- Cefotaxime + Gentamicin Moderate
- Cefotaxime + Kanamycin Moderate
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Cefotaxime with Voclosporin?
MediHelp rates the interaction as moderate. Cefotaxime and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin is a calcineurin inhibitor with dose-related nephrotoxicity, and cephalosporins such as cefotaxime may occasionally impair renal function. Concurrent use could add to the risk of kidney injury, especially in patients with lupus nephritis and reduced GFR.
How serious is the interaction between Cefotaxime and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and eGFR regularly during combined use and adjust voclosporin per labeling if renal function worsens. Dose cefotaxime according to renal function.
What other medicines interact with Cefotaxime?
MediHelp also lists interactions of Cefotaxime with, for example, Typhoid vaccine live, Amikacin, Cholera vaccine. The full list is on the Cefotaxime page.
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