Drug interactions
Cefotetan + Fenoprofen
Severity: Minor
Cefotetan and Fenoprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are organic anions cleared by renal tubular secretion, so cefotetan may modestly raise fenoprofen exposure. Cefotetan can also cause hypoprothrombinemia, which adds slightly to bleeding risk with an NSAID.
What this interaction means in plain words
Cefotetan and Fenoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefotetan belongs to Anti Bacterial; Fenoprofen belongs to Musculoskeletal.
Why it happens
Competition for renal organic anion transport; additive hemostatic effects are possible.
What to do
No dose change is generally required. Watch for bleeding and NSAID adverse effects during prolonged therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Cefotetan
- Cefotetan + Dronabinol Contraindicated
- Cefotetan + Warfarin Major
- Amikacin + Cefotetan Moderate
- Argatroban + Cefotetan Moderate
- Cefotetan + Dalteparin Moderate
- Cefotetan + Enoxaparin Moderate
Frequently asked questions
Can I take Cefotetan with Fenoprofen?
MediHelp rates the interaction as minor. Cefotetan and Fenoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both are organic anions cleared by renal tubular secretion, so cefotetan may modestly raise fenoprofen exposure. Cefotetan can also cause hypoprothrombinemia, which adds slightly to bleeding risk with an NSAID.
How serious is the interaction between Cefotetan and Fenoprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required. Watch for bleeding and NSAID adverse effects during prolonged therapy.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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