Drug interactions
Cefpodoxime + Kanamycin
Severity: Moderate
Cefpodoxime and Kanamycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides are nephrotoxic and ototoxic, and cephalosporins have been reported to add to renal injury when combined with them. Kidney function may decline, which in turn increases aminoglycoside accumulation and toxicity.
What this interaction means in plain words
Cefpodoxime and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity, with possible reduced aminoglycoside clearance if renal function declines.
What to do
Monitor serum creatinine and aminoglycoside levels, and assess hearing and vestibular symptoms. Adjust the kanamycin dose to renal function and limit the duration of therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefpodoxime
- Aluminum hydroxide + Cefpodoxime Moderate
- Amikacin + Cefpodoxime Moderate
- Calcium carbonate + Cefpodoxime Moderate
- Calcium + Cefpodoxime Moderate
- Cefpodoxime + Cholera vaccine Moderate
- Cefpodoxime + Cimetidine Moderate
Frequently asked questions
Can I take Cefpodoxime with Kanamycin?
MediHelp rates the interaction as moderate. Cefpodoxime and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides are nephrotoxic and ototoxic, and cephalosporins have been reported to add to renal injury when combined with them. Kidney function may decline, which in turn increases aminoglycoside accumulation and toxicity.
How serious is the interaction between Cefpodoxime and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and aminoglycoside levels, and assess hearing and vestibular symptoms. Adjust the kanamycin dose to renal function and limit the duration of therapy.
What other medicines interact with Cefpodoxime?
MediHelp also lists interactions of Cefpodoxime with, for example, Aluminum hydroxide, Amikacin, Calcium carbonate. The full list is on the Cefpodoxime page.
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